Endocrine Abstracts

Introduction: Metastasis to the thyroid gland is a rare clinical presentation. The most common sites of primary tumors that metastasize to the thyroid gland are kidney, lung, gastrointestinal system and breast. Primary gynaecological tumors are account for only 3% of secondary thyroid malignancies. Here, we present a case of thyroid metastasis from squamous cell carcinoma (SCC) of the cervix.Case: A 54-year-old female was consulted to our clinic with the...

Introduction: Surgical removal of the tumor is the primary treatment modality for insulinomas. However, in some patients, surgery is not possible. Octreotide, a somatostatin analogue, is known to suppress insulin secretion. However, there are little data on the use of octreotide in the treatment of insulinoma. Here, we present an insulinoma patient with severe clinical findings and successful control of hypoglycemia after long-acting octreotide.Case: A 7...

Objectives: Preoperative imaging studies are being commonly used in primary hyperparathyroid patients to increase cure rate and to decrease complication rate of surgery. In this study we correlated the surgical outcomes with localization studies performed by various radiologists.Method: A total of 174 patients with primary hyperparathyroidism in which healing of hypercalcemia achieved by parathyroidectomy were evaluated retrospectively. Since our hospita...

Introduction: Langerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal.Case report: We report a rare case of adult onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental finding of subsequent thyroid gland involvement in the ...

Introduction: IGFs (Insulin like growth factors) are important regulators of pancreatic β-cell development, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. Insulin resistance plays a key role in PCOS. Based on these findings, we aimed to investigate IGF1 gene polymorphism in polycystic ovary syndrome ...

Aim: To evaluate the relationship between glycemic control and quality of life parameters in patients with poorly controlled type 2 diabetes.Methods: Fifty patients with poorly controlled (HbA1c 8–12%) type 2 diabetes included the study and were answered DQOL and SF-36 questionnaires to an assistant in internal medicine. HbA1c levels, age, gender, duration of diabetes, height, weight and waist–hip ratio measurements recorded at the same time.</...

Cycline D1 gene that plays a crucial role in a cell cycle, have been shown to be expressed more in nonfunctioning pituitary adenomas and functioning invasive pituitary adenomas compared to normal hypophisis tissue and noninvasive pituitary adenomas. A/G polymorphism in CyD1 gene exon 4/intron 4 regions have been demonstrated to affect clinical outcomes and survey in some tumors. Objective of this study was to investigate the effect of polymorphism of cycline D1 gene on the tum...

Majority of prolactinomas consists of the small microadenomas that can be treated with dopamine agonists, but they can present different biological behavior features and not infrequently seen as macroadenomas or in giant adenoma size. There are different results on finding of studies which investigate the relationship between high levels of cell proliferation indicators with tumor behavior in pituitary adenomas. In this study, Ki 67 index to investigate the relationship betwee...

Introduction: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance and related disorders. Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflammation. But there are controversial data whether increased the uric acid level in PCOS patients. This study was aimed to examine the relationship between uric acid, lipoprotein l...

In prolactin secreting pituitary adenomas, surgery markedly reduced with the efficacy of dopamine agonists in controlling prolactin hypersecretion and reducing tumor mass. Some surgeons, instead of necessity of almost life-long medical therapy, prefer and recommend surgery as a first line treatment with potentially high success rates especially in microprolactinomas. We evaluated our patients with prolactinoma operated mostly without any evidence of resistance or intolerance t...